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Plants have many advantages for studying eukaryÂotic DNA replication origins and their relationship to structural and transcriptional domains. Plants like Arabidopsis and rice have small genomes that have been or will be fully seÂquenced. Plant tissues at different stages of development and rapidly proliferating, synchroniÂzable cultured cells are readily accessible in quantities amenable for bioÂchemical analysis. We propose to exÂploit these properties to conÂstruct and overlay chromosomal maps of replication origins, matrix attachment regions, modified histones, DNA methylation levels and transcription. |
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